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Follow-up of patients 3 months after stoppage of treatment In glutathione gel treated group
Abbreviations PQC: Protein quality control LONP1: Lon protease 1 ATP: Adenosine triphosphate mtDNA: Mitochondrial DNA UPRmt: Mitochondrial unfolded protein response MTS: Mitochondrial targeting sequence Aco: Aconitase HSP: Heat shock protein NAD: Nicotinamide adenine dinucleotide TFAM: Mitochondrial transcription factor A HIF: Hypoxia-inducible factor COX: Cytochrome c oxidase ETC: Electron transport chain StAR: Steroidogenic acute regulatory protein NRF2: Nuclear respiratory factor 2 EGF: Epidermal growth factor ERK: Extracellular signal-regulated protein kinase PI3K: Phosphatidylinositol 3-kinase m 6 A: N 6 -methyladenosine METTL3: Methyltransferase-like 3 IGF2BP2: Insulin-like growth factor 2 mRNA-binding protein 2 Kcr: Lysine crotonylation PCOS: Polycystic ovary syndrome ROS: Reactive oxygen species Kac: Lysine deacetylation I/R: Ischemia/reperfusion PKA: Protein kinase A PDH: Pyruvate dehydrogenase PDK4: Pyruvate dehydrogenase kinase 4 ER: Endoplasmic reticulum MAM: Mitochondria-associated endoplasmic reticulum membrane OPA1: Optic atrophy 1 Drp1: Dynamin-related protein 1 MFN1: Mitofusin 1 SOD: Superoxide dismutase eIF2: Eukaryotic initiation factor 2 ATF: Transcription factor GLUT1: Glucose transporter 1 HMOX1: Heme oxygenase 1 LDHB: Lactate dehydrogenase B IPF: Idiopathic pulmonary fibrosis AT2: Alveolar type 2 PAI-1: Plasminogen activator inhibitor-1 TGF-: Transforming growth factor- Rb: Retinoblastoma FGF2: Fibroblast growth factor 2 COPD: Chronic obstructive pulmonary disease PERK: Protein kinase R-like endoplasmic reticulum kinase ISR: Integrated stress response CDH: Congenital diaphragmatic hernia PH: Pulmonary hypertension MPC1: Mitochondrial pyruvate carrier 1 tDCS: Transcranial direct current stimulation MCT1: Monocarboxylate transporter 1 PPA: Propionate PTEN: Phosphatase and tensin homolog CODAS: Cerebral, ocular, dental, auricular, and skeletal anomalies HMGB1: High-mobility group box 1 TRPC6: Transient receptor potential cation channel 6 PD: Parkinsons disease TOMM: Translocase of outer mitochondrial membrane AMBRA1: Autophagy and beclin 1 regulator 1 ATAD3A: ATPase family AAA domain containing 3A AD: Alzheimers disease TDP-43: TAR DNA-binding protein 43 FRDA: Friedreich ataxia MELAS: Mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes APAP: Acetaminophen CGA: Chlorogenic acid CCl4: Carbon tetrachloride ACLF: Acute-on-chronic liver failure G6Pase: Glucose 6-phosphatase PCK1: Phosphoenolpyruvate carboxykinase 1 JNK: C-Jun N-terminal kinase IRS-1: Insulin receptor substrate 1 MCD: Minimal change disease DKD: Diabetic kidney disease H 2 S: Hydrogen sulfide CKD: Chronic kidney disease HMGCS2: 3-Hydroxy-3-methylglutaryl-CoA synthase 2 CYP11A1: Cytochrome P450 family 11 subfamily A member 1 AIFM1: Apoptosis inducing factor mitochondria associated 1 OA: Osteoarthritis MAPK: Mitogen activated protein kinase RA: Rheumatoid arthritis ASIC1a: Acid-sensing ion channel 1a NSCLC: Non-small cell lung cancer H
One such study, published in Biomedicine and Pharmacology in 2017, proposes that saponins from asparagus might be a helpful component in preventing secondary tumor formation
To gain a deeper understanding of the cellular mechanisms underlying WD, a reanalysis of the GSE1073236 dataset was conducted and validated by comparative analyses in a cell culture model of HepG2 and HepG2 ATP7B knockout (ATP7B-KO) cells, as well as in primary hepatocytes from WD patients and controls
