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Via the activation of TLR4/MAPK signaling in KCs ( In addition to HSCs, in an injured liver, hepatocytes and bile duct cells can also transform into fibroblasts via the process of epithelialmesenchymal transition (EMT), and excessive extracellular matrix (ECM) deposition by fibroblasts contributes to liver fibrosis

Biochem J 417:113 Ramsay RR (2019) Electron carriers and energy conservation in mitochondrial respiration

1 This is typically a silent disease, often not producing symptoms until its later stages when there is chronic liver injury

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