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Increased intracellular levels of the antioxidant GSH are generated as a consequence of melatonin stimulating -glutamyl cysteine synthetase (the rate-limiting enzyme in GSH formation) and GR (the enzyme converting GSSG to GSH) (314, 315)
In that sense, HRT appears to potentiate the effect of the most common anti-parkinsonian drug, levodopa, reducing its response threshold and enhancing its sensitivity (Tsang et al., 2000
Anti-proliferative effect and diminished malignant transformation are observed after CBS silencing in basal-like breast cancer cells
In many cases, optimizing progesterone first can make testosterone therapy more effective and reduce side effects like irritability, bloating, or water retention
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