The anti-endometriosis effects involve plentiful molecular mechanisms and targets, including anti-proliferative (CCNE1, CDK2, and CDK4), anti-inflammatory (PGE2, COX-2, TNF-, NO, IL-1, IL-6, and IL-8), anti-angiogenic (VEGF, matrix metalloproteinase and Ang-1), pro-apoptotic (Bax, Bak, Bcl-2, Bcl-xL), autophagy (Beclin 1, LC3-II/LC3-I), endoplasmic reticulum stress, endoplasmic reticulum apoptotic pathway, mitochondrial apoptotic pathway and caspase cascade, anti-migratory invasion (MMP-2, MMP-9, TIMP1, E-cadherin, N-cadherin, Snail and Slug), regulation of estrogen and progesterone receptors, and anti-fibrotic (E-calmodulin, -SMA, type I collagen, wave proteins and fibronectin)
Deliberately pushing that pathway harder has a theoretical cancer-risk question attached that has never been studied in humans, because dihexa has never been studied in humans at all
I use the following medications much more sparingly Phenteramine is tolerable short-term but causes frequent dry mouth, palpitations, hypertension and insomnia
Akkermansia muciniphila is a newer probiotic strain gaining attention for gut health support, particularly in the context of metabolic health and GLP-1 medications
3 There are also prescription medications that are made from peptides, which have been carefully studied and monitored
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