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Other pharmacotherapies not based on entero-pancreatic hormones Several therapies that are not based on entero-pancreatic hormones are currently under evaluation for obesity and they represent further therapeutic options, considering their distinct mechanism of WL to the entero-pancreatic hormone therapies

Jiao L, Li X, Luo Y, Wei J, Ding X, Xiong H,

While they can be lifesaving in acute or emergency settings, repeated or long-term use is associated with well-documented steroid side effects affecting metabolic, immune, and musculoskeletal systems

Williams and Asif Nawaz contributed equally

NNMT (nicotinamide N-methyltransferase) is an enzyme that methylates nicotinamide, draining methyl donors and reducing NAD+ salvage