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Act as an anti-aging formula by reducing saggingness of skin

In hindlimb ischemia models, both genetic and environmental circadian disruption impair reparative neovascularization (74)

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For example, Hara et al reported that COL IV stimulates dendricity in human MCs on glass substrates (considered as ultra-hard stiffness) (Hara et al, 1994), while melanin production on stiff PDMS substrates (5.5 MPa) coated with laminin is higher compared to softer counterparts (from 50 kPa to 1.8 MPa) (Choi et al, 2014)