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The C1q induction occurred prior to the appearance of obvious clinical symptoms or major neuroinflammation and could contribute to neurodegeneration [151]

The principal neurological function regulated by GLP-1RA could be summarized as follows ( Figure 2 ): (1) GLP-1RA liraglutide and exendin-4 effectively inhibited neuronal apoptosis (15), and ultimately improved early brain injury by suppressing NLRP3 inflammasome and inflammatory reaction in microglia (3436)

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The relationship between bipolar disorder and the role of monoamines in the disturbance of circadian regulation requires further exploration

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