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This process is driven by disrupted GSH homeostasis, resulting from diminished GSH synthesis and impaired activity of two critical antioxidant systems: (1) the cystine/glutamate antiporter xCT, which imports cystine to fuel GSH production and (2) GPX4, which utilizes GSH to convert lipid peroxides into less toxic lipid alcohols (Stockwell et al., 2017

[1] Despite being non-essential, glycine plays critical roles in normal physiology

Although numerous studies support the beneficial role of acupuncture in modulating PCD, the evidence base remains predominantly preclinical, with a significant translational gap to clinical practice

M., Madeo, F., & Kroemer, G

[PubMed: 11585645] 26