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It enhances both synthesis and breakdown of extracellular matrix components, such as collagen, glycosaminoglycans (including dermatan and chondroitin sulfate), and decorin, and regulates metalloproteinases and their inhibitors (Pickart, Vasquez-Soltero, and Margolina 2015)

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Further, liver tissues were processed for frozen sectioning, hematoxylin and eosin (H&E) staining, and then micrometastases were counted by examination of H&E-stained sections under the microscope