Epigenetic regulation and post-translational modifications of ferroptosis-related factors in cardiovascular diseases
NF-B suppresses GPX4 and system Xc , upregulates TFR1, thereby promoting microglial ferroptosis (Zheng et al., 2024
After 12 treatment sessions, patients were assessed for pain intensity, knee flexion range of motion, a timed up-and-go test, a 6-min walk test, and knee functionality compared to pre-treatment baseline measurements
Age-related vulnerabilitiessuch as reduced renal function, decreased bone mineral density, and a greater risk of sarcopenia and malnutritioncan exacerbate complications associated with a restrictive high-fat diet [209]
N -methyl-D-aspartate receptors (NMDARs) activation leading to intracellular calcium (Ca 2+ ) influx and rapid activation of various protein kinases [e.g., calcium/calmodulin dependent kinases (CaMKs), protein kinases A (PKA), and C (PKC), extracellular signal-regulated protein kinase (ERK)] and phosphatases [e.g., protein phosphatase 1 (PP1), calcineurin] (Ho et al., 2011)