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Engineered PD-1/TIGIT dual-activating cell-membrane nanoparticles with dexamethasone act synergistically to shape the effector T cell/Treg balance and alleviate systemic lupus erythematosus

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It should be noted that in addition to the Na + -dependent and Na + -independent GSH transporters, MRP (multidrug resistance-associated proteins), CFTR (cystic fibrosis transmembrane conductance regulator), and organic-anion-transporting polypeptide (OATP), especially oatp1 in OATP family, can also transport GSH [38] in addition to GSH derivatives such as glutathione disulfide (GSSG), glutathione S -conjugates, glutathione and metal complex [38]

We hypothesized that this reaction might occur in vivo, affecting endogenous GSH as well as limiting the reactivity of free FA

References Pickart, L., Vasquez-Soltero, J