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5153 Unfortunately, acarbose/miglitol therapy is often not tolerated due to side effects such as bloating, gas, and abdominal discomfort, especially when carbohydrate intake remains high

Although systemic inflammation is known to modulate iron metabolism, such as interleukin-6 (IL-6) stimulating hepcidin synthesis and subsequently downregulating FPN1, this has been observed primarily in hepatic tissues (95)

Summary Table If you are looking for a quick final verdict based on current biological models, here is the ultimate breakdown: Key Takeaways Main takeaway: MOTS-c is a natural systemic metabolic optimizer

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