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It affects mostly adults over the age of 60

The FDA's adverse event database does not list mood swings as a primary or frequent side effect, though individual case reports exist

Moreover, carotenoids that do not function as substrates (e.g., canthaxanthin, zeaxanthin) interfere with retinol conversion (by inhibiting carotene dioxygenase), whereas protein-energy malnutrition hampers retinol circulation (by affecting plasma levels of retinol-binding protein)

Injection site reactions mild redness, swelling, or itching at the injection point

The SKIMS founder spoke in a June 21, 2022, interview on the TODAY show about her major weight loss ahead of the 2022 Met Gala, when she shed 16 pounds in three weeks to fit into Marilyn Monroe's iconic dress