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Also affects fat tissue , promoting fat breakdown (lipolysis) for energy

General guidelines and dosing for patients with T2D: Initiate pramlintide at the 60 mcg dose taken immediately prior to major meals Titrate pramlintide to 120 mcg dose after 3 or more days with no clinically significant nausea Optimize insulin to achieve glycemic targets once the maintenance dose of pramlintide is reached and blood glucose concentrations are stable Practical Tips for Patients On Pramlintide Start With a Low Dose and Titrate Slowly Pramlintide can cause nausea, anorexia and vomiting, especially in T1D where a more gradual titration is required

Use desiccants with powders, keep lids tight, prefer single-dose packets for liquids, and avoid fluctuating temperatures whenever possible

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Physical activity stimulates peristalsis through mechanical vibration, increased blood flow to the gut, and activation of the parasympathetic nervous system