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As a systematic review by the Cochrane Library noted: The small number of trials, low event rates and wide confidence intervals around the estimates mean that our confidence in the result is rated low. For example, there were weaknesses in the randomized trials

The difference between the two our residual must be explained

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2,12 In 2009, the Canadian Expert Panel on Tobacco Smoke and Breast Cancer Risk reported that the association between smoking and BC was consistent with causality