Common Side Effects The most frequently reported side effects of GLP-1 medications include: Nausea (most common, especially during dose escalation) Vomiting Diarrhea Constipation Abdominal pain Decreased appetite Fatigue Headache Serious Risks and Contraindications GLP-1 medications carry boxed warnings and contraindications that patients must discuss with their healthcare provider: Thyroid C-Cell Tumors: Semaglutide and tirzepatide carry a boxed warning about thyroid C-cell tumors observed in rodent studies
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This duration is considered adequate to observe meaningful weight loss while also assessing the medications long-term safety profile
Is the medication compounded or an FDA-approved branded product
Authored by: Sergey Terushkin, MD, FACS, FASMBS, DABOM, DABS-FPMBS Key Takeaways Average Timeline: Clinical trials show losing 50 lbs on tirzepatide takes about 72 weeks, with higher doses delivering greater results
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