Functionally, MAPKAPK2 overexpression mitigated oxidative damage, restored antioxidant capacity, and attenuated markers of DNA damage and cellular dysfunction, suggesting a cytoprotective role under oxidative conditions
It has been proposed that the PI Z variant may aggregate into polymers that precipitate and accumulate in cutaneous soft tissues, leading to inflammation and necrotizing skin lesions ( A1AT is the most abundant serum serine protease inhibitor with anti-protease property ( Figure 1 ) ( Figure 1 Data on the safety of A1AT replacement therapy remain limited due to the rarity of the underlying condition, which currently has only one approved indication for treatment
Mahmood A, Needham J, et al
Human COQ4 deficiency: delineating the clinical, metabolic and neuroimaging phenotypes
848 These suggest that NCOA4 may contribute to intestinal I/R injury in mice by inducing ferroptosis through mediating ferritinophagy
