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By inhibiting the NF-B pathway and competitively antagonizing pro-inflammatory metabolites of arachidonic acid (such as PGE and LTB), they exert anti-inflammatory and cartilage-protective effects (39, 40)

PMID 9606808

Appl Environ Microbiol 63:29712976 Ike A, Sriprang R, Ono H, Murooka Y, Yamashita M (2007) Bioremediation of cadmium contaminated soil using symbiosis between leguminous plant and recombinant rhizobia with the MTL4 and the PCS genes

For researchers who are not seeing expected results, storage evaluation should be the first troubleshooting step, before considering dose changes, switching medications , or adding supplementary compounds like B12 formulations or niacinamide combinations