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These preclinical results have been confirmed and extended in human studies in which GLP-1 receptor agonists reduce alcohol intake in patients with alcohol use disorder (AUD) who have a regular weight or comorbidity of obesity or type 2 diabetes

26 It is also feasible that reduction in AMD risk factors such as obesity, cardiovascular disease, and hyperlipidemia with GLP-1RAs could further provide benefit by reducing systemic inflammation and vascular risk factors

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