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The use of alternative models to study meningococcal pathogenicity outside of a living organism, including organoids, tissue cultures, and ex vivo organ culture systems, could help us confirm observations made in cell line infection studies using traditional systems

NEDD8 modification induces conformational remodeling of the CUL5RBX2 complex, alleviating its autoinhibited state and exposing an interface competent for binding the E2ubiquitin (E2Ub) conjugate

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Composed of three amino acidsglutamine, glycine, and cysteineit plays a crucial role in protecting cells from oxidative stress, detoxifying harmful substances, and supporting overall cellular health

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