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After a two week adjustment period the test subjects were assigned to a group receiving either a placebo treatment or 0.25 mg, 0.5 mg, or 1.0 mg of tesofensine

Abstract N -nitrosamine (NA) impurities in pharmaceuticals represent cohort of concern compounds under ICH M7(R2), due to their mutagenic/carcinogenic potential, involving cytochrome P450 (CYP)-mediated metabolic activation

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These may include confusion, depression, difficulty recalling or remembering information, and tiredness