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17 Randomized placebo-controlled trials have noted L-arginine, at doses of 1.52.4 grams per day, led to a small but significant positive impact on symptoms in some patients with IC/BPS

This combination can enhance the growth and activity of beneficial gut bacteria more effectively than prebiotics or probiotics alone[193]

In a rat model of IBS, intraperitoneal administration of exendin-4 normalized stress-induced defecation and visceral pain sensitivity by modulating enteric neuronal function through GLP-1 receptors in submucosal and myenteric ganglion neurons [52]

Collagen: 40 mg

Vitamin B12 Status Upon Short-Term Intervention with a Vegan DietA Randomized Controlled Trial in Healthy Participants. Nutrients 11.11 (2019): 2815