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Randomized double-blind placebo-controlled trial of acetyl-L-carnitine for ALS

Key safety signals observed in the Phase 2 trial included gastrointestinal adverse effects (nausea, vomiting, diarrhoea, and constipation), increases in resting heart rate, and gallbladder-related events consistent with the broader class of incretin-based therapies

In addition, the authors validated the genome predictions with experimental data from sixteen human gut microorganisms, published elsewhere, showing that 88% of the predictions matched 34

Recent animal and clinical data show that mixed-fiber supplementation can restore metabolic stability and cognitive function