While the 20 different Zyn products authorized for marketing and sale in the US received FDA authorization for marketing as a modified risk tobacco product (MRTP) in June 2026, they are only allowed to make the specific claim that, Using ZYN instead of cigarettes puts you at a lower risk of mouth cancer, heart disease, lung cancer, stroke, emphysema, and chronic bronchitis. No other oral nicotine product has been granted an MRTP order
Arnson Y, Shoenfeld Y, Amital H
Spit tobacco includes snuff, a finely ground version of processed tobacco, and chewing tobacco in the form of shredded or pressed bricks and cakes, called plugs, or rope-like strands called twists
Current Opinion in Oncology
Chronic-pain patients on high doses of opioids