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NH2-truncated human tau induces deregulated mitophagy in neurons by aberrant recruitment of Parkin and UCHL-1: implications in Alzheimers disease

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The Triple Culture (TC) models included activated primary blood-derived macrophages (TC pBDMs) or activated human THP1 macrophages (TC THP1) on the apical side along with the alveolar epithelial cells, all maintained under ALI + Str conditions (Fig