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Some may notice changes in skin texture and hydration within 12 weeks, but collagen remodeling and deeper changes may take 412 weeks with consistent use

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Eur J Cancer 42(15):26232630 Paolicchi A, Lorenzini E, Perego P, Supino R, Zunino F, Comporti M, Pompella A (2002) Extra-cellular thiol metabolism in clones of human metastatic melanoma with different gamma-glutamyl transpeptidase expression: implications for cell response to platinum-based drugs