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Unlike pepsin, a well-known gastric Asp protease that cannot break down these Pro-rich gluten peptides, RmuAP1CD appears to tolerate Pro residues near the scissile bonds, the specific peptide bonds targeted and cleaved by proteases (Ali et al

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In this review, we attempt to make a succinct summary of all such information below

They may remain normal in GSTT1 null individuals if exposures are low and other detox systems compensate, and they can be abnormal in GSTT1 present individuals if toxic load or other stresses are high