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Nicotine-induced weight loss is a result of reduced appetite signalling in the hypothalamus and increased energy expenditure owing to increased locomotor activity, increased thermogenesis of brown adipose tissue, increased expression of UCP1 and UCP3 in brown adipose tissue and alterations in the utilization of fuel substrates 29,37

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Use of Vaping as a Smoking Cessation Aid: A Review of Clinical Trials

Trials of smoking-reduction interventions have also found that these can lead to increased quitting when combined with nicotine replacement therapy