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However, gJHM complications showed an overall lower rate with the exclusion of pes planus (present in most patients) and recurrent inflammatory soft-tissue injuries, among which plantar fasciitis, bursitis, and tenosynovitis were particularly frequent

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The involvement of residues from multiple transmembrane helices (TM3, TM5, TM6, and TM7) in ligand binding is consistent with the activation mechanism of class A GPCRs 35