semaglutide recombinant synthesis CN115322250A - method of The 6 Billion Dollar Synthesis

the fermentation may be carried out in fed-batch to produce expressed semapeptide

Notable exclusions include antibodies, label expansion, biosimilars

Feed was added to fermenter on rise of pH and DO

WO2022064517A1 - A process for the preparation of semaglutide and semapeptide - Google Patents A process for the preparation of semaglutide and semapeptide Download PDF Info Publication number WO2022064517A1 WO2022064517A1 PCT/IN2021/050924 IN2021050924W WO2022064517A1 WO 2022064517 A1 WO2022064517 A1 WO 2022064517A1 IN 2021050924 W IN2021050924 W IN 2021050924W WO 2022064517 A1 WO2022064517 A1 WO 2022064517A1 Authority WO WIPO (PCT) Prior art keywords tag arg formula glp semapeptide Prior art date Legal status (The legal status is an assumption and is not a legal conclusion

By creatively splitting 31 amino acids of a main peptide chain of the semaglutide are into a 3-site amino acid polypeptide chain (MI chain) and a 28-site amino acid polypeptide chain (MII chain), the possibility of efficiently and quickly preparing the semaglutide under an escherichia coli preparation system is realized