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Cooperative interactions with multiple binding partners enable high specificity by low-affinity interactions, which appear to be crucial for AR activity 32,35

Besides, estradiol and estrone can be interconverted by 17-hydroxysteroid dehydrogenase, and estriol is primarily produced from the other two during pregnancy (24)

Lyophilized peptides, by contrast, freeze well

By contrast, particles with aerodynamic diameters smaller than 1 m often remain suspended in the airstream and are exhaled without deposition, with diffusion being the primary mechanism for their deposition 129

9,13 These drugs have not been FDA approved for use in children and adolescents, but have been used