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PMID: 35 TieJ.LiS.HeW.LiY.LiaoF.XueJ.et al

Moreover, as filtered cigarettes reduce irritation, taste more pleasant and are perceived healthier, filters encourage people to smoke more cigarettes per day (32, 33)

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NNK induces IDO1 in lung epithelial cells in vitro and in vivo IDO1, IDO2, tryptophan 2,3-dioxygenase (TDO), and tryptophan hydroxylase 1 (TPH1) play important roles in Trp metabolism

The main distinction is that psychological dependence relates to the emotional obsession and mental desire for substance use, whereas psychological addiction is marked by a pathological, uncontrollable compulsion to use a substance despite the harmful effects