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For instance, this group demonstrated that upon AgNPs exposure, there was upregulation of cellular metal-ion association with a significant increase in metallothionein genes that didnt induce a significant inflammatory response, indicating that AgNPs can be safely used (Fig

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[4] In differentiated 3T3-L1 mouse adipocytes, 5-Amino-1MQ lowered intracellular 1-MNA in a concentration-dependent manner with an EC 50 of 2.3 1.1 M (R = 0.94)