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Its side effects are largely gastrointestinal: Oily stools Urgent or frequent bowel movements Abdominal cramps Orlistat is not absorbed systemically, so systemic side effects are rare

Exp Neurol 203(1):2233 Carmichael J, Fadavi H, Ishibashi F, Shore AC, Tavakoli M (2021) Advances in screening, early diagnosis and Accurate Staging of Diabetic Neuropathy

They found that genetic knockdown of USP30 increased CNS mitophagy, protected against dopaminergic neuron loss, and reduced -synuclein aggregation

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