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Furthermore, although the studies included in this meta-analysis have statistically adjusted for key covariates, including age, gender, race, education level, and so on, and conducted subgroup analysis based on traditional smoking history, thereby strengthening the inference of an association between exclusive e-cigarette use and COPD prevalence, the possibility of residual confounding still exists

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ASH (2025) 2025 ASH Year 10 Snapshot Survey

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(2) always crushing the flavour capsule while smoking (flavour capsule users only)