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For example, the Wnt/-catenin pathway is involved in BBB integrity, synapse assembly, synapse functions, synaptic plasticity, neurogenesis, white matter lesion remyelination, dopamine neuron neuronal survival protection, and regeneration, whereas aberrations in the Wnt/-catenin pathway are associated with synaptic loss, BBB breakdown, and neurodegenerative disease, including Alzheimers and Parkinsons disease (6468)

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Building on the understanding that GLP-1 agonists induce weight loss through appetite suppression and slowed gastric emptying, it is crucial to recognize the potential downstream consequences of these mechanisms, particularly regarding nutritional status

JCI Insight 5 , (2020)