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Clin Drug Investig 37(12):11911201 Baron R, Jansen JP, Binder A et al (2016) Tolerability, safety, and quality of life with tapentadol prolonged release (PR) compared with oxycodone/naloxone PR in patients with severe chronic low back pain with a neuropathic component: a randomized, controlled, open-label, phase 3b/4 trial

This combination produces synergistic healing effects exceeding either peptide individually by approximately 30% according to user reports

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Improved sleep quality and mental focus often occur within the first 1 to 4 weeks

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