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The key features that distinguish paraptosis from classical apoptosis include its independence from caspase-9 activation, the absence of typical apoptotic markers such as chromatin condensation or DNA laddering, and cytoplasmic vacuolisation as the predominant morphological feature positively modulated by the mitogen-activated protein kinase (MAPK) signalling pathway [119]

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Running alongside these is TRIUMPH-CVOT, a separate cardiovascular outcomes trial enrolling around 10,000 participants with established cardiovascular disease over 3-4 years

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