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Third, one class in each grade of the selected school was randomly identified and all the students of the class were potential participants

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No adverse effects were associated with nicotine e-cigarettes

Scientific evidence published in peer-reviewed cardiology journals shows that nicotine increases heart rate, constricts blood vessels, and raises blood pressure, even in young people without underlying conditions

Differential or nonrandom misclassification may either increase or decrease estimates of effect, while random misclassification tends to reduce the apparent effect and weaken the relationship of exposure with disease risk