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Adjusting the treatment plan as needed Dose escalation should be dependent of patient side effect profile and gastrointestinal tolerability

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Isolation of rat heart mitochondria Upon cervical dislocation of 912 weeks old male Wistar rats (Charles River, UK), heart mitochondria (RHM) were prepared by homogenization of their heart tissue in STEB buffer (250 mM sucrose, 5 mM Tris-HCl and 1 mM EGTA, pH 7.4) supplemented with 0.1% fatty acidfree BSA

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Effect of 26 weeks of liraglutide treatment on coronary artery inflammation in type 2 diabetes quantified by [ 64 Cu]Cu-DOTATATE PET/CT: results from the LIRAFLAME trial