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Headache Dizziness Mood changes Acne Increased hair growth Slow healing of cuts or wounds Tiredness or weakness Changes in menstrual periods Fluid retention Elevated blood sugar Stomach discomfort Long-Term Risks Prednisone use is associated with an increased risk of serious health problems, including: An increased risk of infections due to suppression of the immune system Stomach ulcers and gastrointestinal bleeding Decreased bone density and increased risk of osteoporosis, leading to fractures Fluid retention Low potassium Slowed growth and development in children Safety and Precautions Prednisone may not be suitable for people with certain conditions, including infections, diabetes, osteoporosis, seizures, myasthenia gravis, kidney or liver disease, thyroid disorders, or gastrointestinal issues