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Its superoxide-mediated oxidation generates the fluorescent product 2-hydroxyethidium (2-E + OH) ( excitation = 500 nm, emission = 600 nm), while other ROS or reactive nitrogen species (RNS) do not form the same fluorescent product when reacting with DHE (Zhao et al., 2003

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Compound-level evidence does not validate a stack

The functional GDH is a hexamer structure composed of two sets of trimers, with each trimer containing ~ 500 amino acids and each monomer possessing a guanosine triphosphate (GTP) binding site and a nicotinamide adenine diphosphate hydride (NADH)/adenosine diphosphate (ADP) binding site, enabling binding of 6 GTP molecules, 6 ADP molecules and 6 NADH molecules with GDH hexamer at its respective allosteric binding sites

doi: 10.1007/bf02784608 25 LiuYLiuSMaoJPiaoSQinJPengSet al