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Preclinical mouse models have confirmed that e-cigarettes increase the infectivity of Pseudomonas aeruginosa , Streptococcus pneumoniae , Staphylococcus aureus , human rhinovirus (HRV), and respiratory syncytial virus (RSV) [42, 47]

, dopamine, norepinepinephrine, acetylcholine, GABA and glutamate) in the reward/addiction pathways and involved in cognition, as well as activation of nicotinic receptors at the neuromuscular junction (Figure 2)

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