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Compared with healthy controls, patients with COPD had lower PGC-1 mRNA expression in skeletal muscle, accompanied by reduced TFAM protein levels, which may be linked to decreased muscle oxidation capacity in COPD (Remels et al., 2007)

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This exposure level is staggering, and the studys authors concluded that people who smoked the original version of this cigarette faced possible substantial exposure to crocidolite and should be warned of the risk