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doi: 10.1007/s00281-017-0624-2 15

Mutant IDH1 leads to the accumulation of the metabolite 2-hydroxyglutarate (2-HG), which stabilizes HIF-1, further promoting immune suppression in the TME

*Note: This is NOT a complete list and we have not used any branded names as new drugs are released so frequently that it is not possible to keep up

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