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The mechanisms behind these associations suggest that oral bacteria and their metabolites can enter the bloodstream through oral epithelial barriers or via direct interactions with the respiratory and digestive systems, thereby influencing systemic health [33,34,35]

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Additionally, the increased risk of mortality among e-cigarette users may be due to underlying, pre-existing comorbidities related to prior combustible cigarette use
Indeed, although the level of nicotine captured by silicone wristbands worn by children in vaping households was less than that for cigarette homes, it was still several-fold higher than for children residing in nonsmoking/nonvaping homes (159, 160)