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FDA guidelines

From a patient safety point of view, it is important to notice that intake of up to 400 ml of the beverage does not produce negative effects on the gastric content compared with a similar intake of water 16,24

"Harm Minimization and Tobacco Control: Reframing Societal Views of Nicotine Use to Rapidly Save Lives"

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Bupropion yields better results than Varenicline when combined with nicotine replacement therapy and using both Varenicline and Bupropion at the same time does not increase the success rate of quitting smoking nor does it show any substantial benefits.