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Daily administration of two or more synaptogenic compounds simultaneously might overwhelm cellular synthetic capacity or trigger compensatory downregulation faster than either compound would alone, potentially favoring alternating administration schedules where different compounds are used on different days

And if you're urinating a lot on account of drinking, you can lose a lot of fluids and disrupt your bodys balance of sodium

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However, another meta-analysis including 13 RCTs found that GLP-1RAs had a neutral effect on the occurrence of AF in populations with obesity or overweight and without diabetes [31]