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Recent data suggested that AGEs significantly increased DPP-4 expression and sDPP-4 release by tubular cells, whereas AGE and RAGE expression levels are reduced in the kidney of DPP-4-deficient diabetic rats, suggesting the existence of a cross-talk between the AGERAGE axis and DPP-4 in the pathogenesis and progression of T2D [56,57]

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To determine the intensity of inflammation that promotes the formation and long-term persistence of NETs (Oliveira de Sousa et al

JAMA , 325 (14), 14141425