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The above considerations emphasize the need for early engagement between regulators and the regulated community when utilizing NAMs as part of regulatory filings

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Finding that the vast majority of cases of oral cancer were caused not by the use of snuff or chewing tobacco of tobacco but by smoking cigarettes, Rodu (now professor and endowed chair in tobacco harm reduction research at the Brown Cancer Center of the University of Louisville) proposed a public health strategy to encourage cigarette smokers to switch to moist snuff, which had been cleverly re-named smokeless tobacco [as in smoke less and no smoke] in the late-1970s by the United States Tobacco Company (UST), maker of the best-selling brands SKOAL and Copenhagen

Supporting data are considered essential in demonstrating that a tobacco product is Appropriate for the Protection of Public Health (APPH), the relevant product standard for tobacco products employed by the U.S

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